1. Piracetam - Piracetam is probably one of the best-known nootropics within the nootropic community, however, if you’re new to the scene, you may never have heard about it. Piracetam is one of the oldest nootropics available, and has formed an entire family of other nootropic drugs with similar methods of actions. This family is called the “Racetam” family and consists of a dozen or so other chemicals. Piracetam has been proven non-toxic and shown to effectively increase cognition in mentally healthy individuals.
For a detailed history and information about Piracetam, check out the Piracetam page.
2. CDPCholine - Acetylcholine is one of the brain’s primary neurotransmitters. If your brain is running low on Choline, you’re simply not going to be functioning well. A lot of different nootropics are based around choline, whether they’re choine supplements (adding to the amount of choline available) or affecting the interactions of choline in the brain. Some nootropics focus on preventing the breakdown of choline in the brain, which effectively increases the amount of choline available. CDPCholine is a choline supplement, so it increases the amount of choline available to the brain. It is important to take a choline supplement such as CDPCholine with racetam drugs, since these drugs seem to cause the brain to use up choline at a higher rate.
For a detailed history and information about Piracetam, check out the Piracetam page.
2. CDPCholine - Acetylcholine is one of the brain’s primary neurotransmitters. If your brain is running low on Choline, you’re simply not going to be functioning well. A lot of different nootropics are based around choline, whether they’re choine supplements (adding to the amount of choline available) or affecting the interactions of choline in the brain. Some nootropics focus on preventing the breakdown of choline in the brain, which effectively increases the amount of choline available. CDPCholine is a choline supplement, so it increases the amount of choline available to the brain. It is important to take a choline supplement such as CDPCholine with racetam drugs, since these drugs seem to cause the brain to use up choline at a higher rate.
3. Pyritinol – Pyritinol was developed based around the vitamin B6. Its basically two vitamin B6 joined together. It’s able to easily cross the blood/brain barrier. Pyritinol has direct effects on promoting energy, wakefulness, and concentration. It’s proven safe and effective. Even in large dosages, it is still quite safe.
For more information on Pyritinol, check out the page on Pyritinol



Great website; interesting. I would add caffeine/theanine to this list.
Thanks Brandon!
Great blog. i think it fills a real gap. I read longecity and mindandmuscle, but having concepts in a clear narrative like this is a huge help. Thanks!
Thanks so much Max! It means a lot to hear we’re making a difference.
Based on just wondering if there are more such ready-made ‘guides’ available? – If not, it may be a *very good* idea to consider here. –Cheers
Correction: I meant to write:
“Based on [a href="-link below-" title="this"] was wondering if there are more such ready-made ‘guides’ available? – If not, it may be a *very good* idea to consider here. –Cheers
link: http://www.amazon.com/review/R2UT794O8QKLRV/ref=cm_cr_rev_detmd_pl?ie=UTF8&asin=B0057J89PW&cdForum=FxEX1ITBEASELT&cdMsgID=Mx391UOTQUQIT18&cdMsgNo=5&cdPage=1&cdSort=oldest&cdThread=Tx3H3D81ZA2DGUT&store=hpc#Mx391UOTQUQIT18
Regards again.
[...] PIRACETAM + CDP-CHOLINE — Piracetam is a safe and effective cognitive enhancer that is thought to restore membrane fluidity of compromised neuronal cells (helping with neuro- transmission, protection, and plasticity). It was first used in the 1960′s to combat motion sickness. Its companion (I’ve listed them together intentionally) is CDP-Choline, which is a choline supplement, so it increases the amount of choline available to the brain. (Choline, or Acetylcholine, more properly, is one of the primary neurotransmitters in your brain; without sufficient choline, your brain can’t function well.) [Read more about both of these substances, including how they work together, at SmarterNootropics.com] [...]
[...] you have read 3 Nootropics Everyone Should Know About you have already had a brief introduction to two commonly used nootropics that are made from two B [...]