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Alpha BRAIN Review

Alpha Brain is one of the more well known Nootropics on the market today.  It’s gotten a lot of attention from athletes and celebrities like Joe Rogan and his cohorts over at Death Squad.  The question is whether or not the product lives up to the hype. My experience with Alpha brain is limited to a couple doses I took when my brother purchased a bottle about a year ago. The supplement claims a large amount of benefits including, increased focus, memory, enhanced sleep with more vivid, lucid dreams as well as increased athletic performance and antioxidant benefits.  Lets take a look and see if there’s any evidence to back up these claims.

Alpha Brain ingredients at a glance:

Alpha GPC
There is a lot of evidence to support that Alpha GPC increases acetylcholine levels in the brain, most of this evidence comes from research to help treat cognitive problems and certain types of amnesia.  Alpha brain claims the increase in acetylcholine is what causes dreams to be more lucid and vivid. There isn’t large study to confirm it’s affect on REM sleep but testing on lab mice shows Alpha GPC does counteract the decrease of acetylcholine in the hippocampus and cortex. Is Alpha GPC effective: It does seem effective in increasing levels of acetylcholine in the brain.

Huperzine A
The Huperzia Serrata a type of Chinese moss that Huperzine A is derived from has been used by Chinese herbalists and healers for centuries as fever reducer and an anti-inflammatory. Huperzine A is an alkaloid compound that has been proven to be a potent acetylcholinesterase inhibitor and a very useful tool in combating cognitive disorders like Alzheimer’s. Is Huperzine A effective: Yes

[Editor’s Note: it’s come to our attention that Huperzine A may not be safe to take on a daily basis]

There aren’t a huge amount of clinical trials with Vinpocetine. There is one that studied the ability to increase blood flow to the brain in stroke victims, while the results weren’t hugely significant it did show that Vinpocetine increased blood flow more than the placebo administered. Is Vinpocetine effective: Possibly but not enough evidence to say conclusively

a water soluble compound derived from Cat’s Claw or Una de Gato. AC-11 and other derivatives from Cats claw like C-Med-100 have been shown to reduce cell damage and cell death from harmful elements like UV exposure. AC-11 is able to regulate both anti-inflammation and DNA repair simultaneously, making it a perfect candidate for care products like sun screen and other forms of cancer prevention. Is AC-11 effective: It would seem that it is effective in DNA repair yes

Studies suggest that the use of Bacopa can help memory retention, specifically in people 40 – 65. It’s also been helpful in the reduction of beta-amyloid deposits in animal brains inflicted with Alzheimer’s. Is Bacopa effective: yes

A Phosphilid species associated with multiple membrane related functions including cell excitability and communication. Phosphatidylserine also plays some role in the regulation of neuroendocrine responses that release acetylcholine, dopamine and noradrenaline. is Phosphatidylserine effective: yes

Has a good amount of clinical studies to support it’s claim as an antioxidant and free radical scavenger. is Pterostilbene effective: yes

An amino acid that has been used in clinical studies dealing with weight loss, stress relief and mental disorders. Most studies have dealt with L-tyrosine’s role in the production of dopamine. is L-Tyrosine effective: Yes

An Amino acid most commonly found in Green Tea. L-Theanine has been shown to decrease serotonine levels and increase Alpha brainwaves which are associated with Human relaxation. Is L-Theanine effective: yes

Oat Straw
There are lots of Claims of Oat Straw lowering cholesterol naturally and as an anti-stress medication used to treat hypertension and insomnia but there is little clinical evidence to back any of these claims up.  It is one of the lower ingredients on the list and even if it does not do what it claims by Alpha Brain I can’t imagine it’s addition being harmful in any way. Is Oat Straw effective: can’t say for sure not enough backing information

Vitamin B-6
The most well known ingredient on the list, Vitamin B-6 is essential in metabolic processes of Amino acids, hemoglobin synthesis, gene expression and more. Is vitamin B-6 effective: yes

Anecdotal Evidence:
I’ll say that the two or three days I took Alpha Brain I did feel more focused and energetic although I never experienced any of the lucid dreaming or heavy REM sleep experiences, I also don’t exercise regularly enough to know first hand if it was helpful in that regard.

The science behind Alpha Brain seems legit.  Doing the research certainly piqued my interest and makes me consider trying the supplement again. Every ingredient on the list save for Oat Straw seems to have several clinical trials under it’s belt. The majority of the ingredients all have a history of being used to help find more effective treatments for mental disease, in particular many of the substances are used to help combat Alzheimer’s. I’d say that if your interested in trying a Nootropic and you have the money to spend on AlphaBrain then it’s a worthy investment.

[Editor’s Note: There is some speculation that Huperzine A might not be healthy to take on a daily basis, so please research Huperzine A further before taking Alpha Brain]



  1. Mitch   •  

    Alpha brain has a pretty solid list of ingredients, but it’s so expensive that you’re better off formulating your own or taking the actives individually. You probably don’t want to be taking huperzine-A everyday either, whereas you do want to take some of the other compounds.
    By the way, it’s “piqued my interest” rather than “peeked my interest”.

    • mike   •  

      Thanks Mitch! We missed that spelling mistake in editing but have taken care of it now.

      It’s certainly cheaper to roll your own stack of ingredients compared to purchasing Alpha Brain but there’s also a lot of work when measuring out your own ingredients all the time which may not appeal to everyone.

      We’re attempting to review a large number of the commercially available supplements and compare them all.

  2. eek   •  

    Actually, what would actually be more interesting – are the dosages significant?

    I’d also like to note that you are not being transparent with your recommendation.

    • mike   •  

      Eek, thanks for writing. I had Max review Alpha Brain without any instructions or knowledge about the banners in order to write an impartial article. I think dosages would be good to add and I will work with him to expand the article to discuss whether or not the dosages are at effective levels. I’ll also add in a little bit more price discussion.

      In terms of transparency, I appreciate you letting me know that it wasn’t. It was not my intention to trick or mislead, and therefore until a time as the article is rewritten to not be misleading, I have removed all Alpha Brain banners and links from the website and replaced them with google ads in order to remove this conflict of interest.

      I appreciate your writing and feedback,

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