Modafinil (Provigil, Modalert) vs Armodafinil (Nuvigil, Waklert)
Before delving into the pointers, it’s important to discuss the differences between Modafinil and Armodafinil. Modafinil is a 50/50 racemic mixture of S isomer and R isomer modafinil while armodafinil contains the R isomer only.
One study comparing the two suggests that modafinil suggested that armodafinil had a greater peak in blood levels than modafinil (cmax 5.44 ug/ml vs 4.61 ug/ml respectively), the study also showed the total area under the curve was 40% greater for armodafinil. Interestingly modafinil also demonstrated a biphasic elimination, with S isomer being depleted first and R isomer being last. R isomer modafinil is typically 3 times longer lasting than the S isomer modafinil.
In summary, on a milligram for milligram basis, armodafinil could be considered to be 40-50% more potent than modafinil.
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Modafinil Makes Me Anxious
I suspect I’m not the only one as well. It’s certainly worse when I’m not sleep deprived (i.e when I’m taking modafinil for enhancement rather than to support a normal state). I’ve found that 500mg of Phenibut taken around an hour or two after my modafinil is highly effective and virtually eliminates the anxiety issue.
Less Is Sometimes More
Ideally you should be looking to take the minimum effective dose for your needs. The two main reasons are to avoid side effects and to minimise tolerance. Consider taking a half tablet (100mg modalert / 75mg waklert) before trying out larger doses.
Creativity Cancelled – Focus Enhanced
After experimenting with modafinil for the better part of a year, I can safely say it enhances my focus, concentration and ability to stay awake.
With a 100mg+ dose of modalert I find my ability focus on the minutia is enhanced and I become borderline obsessed with getting the job done. I find modafinil aids my ability to “power through” boring and repetitive tasks while reducing the impact of distractions in my life.
However, I quickly realised that modafinil doesn’t enhance my creativity. My ability to think outside the box is vastly reduced on modafinil. In other words, I lose sight of the “big picture”. This can be considered both a good and a bad thing depending on your requirements. I tend to find that lining up my days tasks in the morning, taking modafinil, then systematically working through them works best.
Modafinil works best when used sporadically. Prolonged use will likely result in diminished effectiveness. Most users will find using modafinil once a week keeps you sensitive. Still, there are people who wish to take modafinil for extended periods, in these instances consider cycling modafinil to maintain sensitivity and reduce tolerance. Some example cycles below:
Short Term Modafinil Cycle
- Maximum 3 days Per week
- Increase doses over the week if tolerance sets in
- Take a 3-5 day break if 200mg has no effect.
- Monday – 100mg
- Wednesday – 150mg
- Friday – 200mg
Long Term Modafinil Cycle
- Maximum 2 weeks “On” one week “Off”
- Increase doses if required.
- Retest tolerance after a full 7 day washout.
- Days 1-7: – 150mg/Day
- Days 7-14: – 200mg/Day
- Days 14-21: – No modafinil / washout
- Day 21/22: – Test tolerance with a small dose. Day one starts if effective. If ineffective, consider a further 7 days off.
Please note these are just example cycles. Everyone’s tolerance is a little different. Get a feel for how the drug works for you personally before attempting any prolonged use.