It’s impossible to get much done with an anxious state of mind. Below are three stacks designed to quell anxiety and keep you calm and relaxed.
Of the three stacks, the initial first stack is nutrient based and non habit forming, designed to be taken every day. The second stack, bar selank, is also non habit forming, but designed for a more cognitive enhancing edge rather than just a calm state of mind.
The third stack is the most potent by far and is only to be used sporadically as tolerance will develop with frequent enough use.
Stack #1 – Daily Base Stack
About The Stack
All of the compounds listed in this stack are free from tolerance and work to reduce anxiety without sedation. Magnesium and omega 3 will take a week or two to reach full effect, particularly if you have existing deficiencies. L-Theanine and glycine’s effects are acute, generally felt 45 minutes from the first dose.
About Omega 3: In short, omega 3 regulates inflammation, may raise BDNF and has been demonstrated to reduce the stress response with individuals suffering with chronic anxiety. Given that EPA and DHA are essential fatty acids, it’s a no-brainier to supplement fish oil or regularly eat oily fish. Learm More: See our Omega 3 Page
Dose: 400-600mg per day.
Where To Buy: USA: iHerb
Where To Buy: EU and UK: SmartNootropics
About Magnesium: An essential mineral that many people under-consume due to changing dietary habits. Magnesium lowers blood pressure via vasodilation, acts as a natural calcium channel blocker and also antagonises NMDA receptors.
Chelated forms of magnesium, such as magnesium glycinate are far more bioavailable than oxide form. If suffering with sleep problems, consider taking half your dose prior to bed time.
About Theanine: A fantastic non-sedating calmative nutrient found naturally occurring in tea. L-theanine promotes alpha brain wave formation, indicating a relaxed, calm state of mind. Theanine is frequently supplemented in a 2:1 ratio with Caffeine to harness the energy caffeine provides and ward off any anxiety it may promote.
Consider 200mg of L-theanine in the day, and a further 200mg prior to retiring if trouble sleeping. The effects of theanine are generally felt within 30-40 minutes. Learn More: See our L-theanine profile
About Glycine: Glycine is an amino acid that’s fairly abundant in the diet. Despite this, 3g around 30-45 minutes before sleep has been repeatedly shown to enhance sleep quality and reduce daytime fatigue. Glycine has been shown to reduce sleep latency in persons with poor sleep quality. As with L-theanine, glycine’s effects are felt on the first dose. Learn More: Check our Glycine Nootropic Writeup
Stack #2 – Cognitive + Calmative Stack
About The Stack
This stack is designed to be taken as a “calming” cognitive enhancement stack that specifically enhances memory and focus. This stack is also able to be super-stacked with stack 1 mentioned previously. This stack does not require cycling, save for the potent Selank which we’d only recommend using sporadically.
About Aniracetam: Aniracetam is both a cognitive enhancer and modest anxiolytic. While mechanisms of action have yet to be elucidated, research shows aniracetam to be an AMPA modulator and a facilitator of cholinergic transmission. In animal studies, aniracetam appears to reduce anxiety and numerous anecdotal reports report the same for humans. Learn More: See Our Aniracetam Profile
About Bacopa: Traditionally consumed as a memory enhancer bacopa strengthens memory, though research shows this to be after chronic administration. As an anxiolytic, bacopa works in as little as two weeks to increase tryptophan hydroxylase and serotonin transporter levels, which reduces anxiety and provides antidepressive effects. Learn More: Read our Bacopa Page
Optional Extra: Selank
About Selank: Selank is little-known anxiolytic peptide developed in Russia. An analogue of an immune system peptide called tuftsin, selank is capable of moluating the immune system, increasing BDNF and increasing serotonin. 2 human studies of selank show it comparable to a benzodiazepine in effectiveness with generalised anxiety disorder (GAD).
Effects are acute, generally 30 minutes. Given that tolerance may develop, we recommend this as an optional extra or something to use “as needed”. Learn More: See Our Selank Profile
Stack #3 –The Serious Business Stack
About The Stack
This stack is designed to be used no more than twice per week, due to the rapid tolerance associated with phenibut. Consider this a nerve calming stack for a job interview, public speaking event, social anxiety or to guarantee a good night’s sleep. Under no circumstances should you use phenibut as a treatment for chronic anxiety. It’s a fantastic substance for sporadic use, but chronic use results in complete tolerance.
About Phenibut: Phenibut is a potent gaba analogue that crosses the blood brain barrier and binds to GABA receptors, specifically to the GABAB receptor. Phenibut takes 2-3 hours to reach peak effects and effects a generally felt for 6-8 hours.
A fantastic anxiolytic, phenibut is the most potent anxiolytic listed on this page by far. Tolerance to phenibut comes fast, do not consume more than twice per week. Do not consume phenibut with alcohol, as both are GABA agonists. Learn More: View Our Phenibut Page
About Theanine: Though admittedly Phenibut is potent enough on its own, the addition of L-Theanine at 200mg rounds this stack off for the most anxious of individuals. As mentioned above, L-Theanine is a modest anxiolytic that the brain doesn’t appear to become tolerant to. L-Theanine promotes alpha brain wave production and a calm state of mind. Learn More: See our L-theanine page
About 5-5HTP: 5-HTP is the precursor to serotonin and is one step closer than dietary tryptophan in a step to serotonin synthesis. A deficiency of serotonin can lead to depression, anxiety and sleep disorders. Taken specifically before bed, 5-HTP supports serotonin and subsequently melatonin synthesis, aiding a good night’s sleep. Do not consume 5-HTP if you are currently taking MAOI or SSRI drugs.