All articles by J


Naturamin – Brain Booster

Mark Pierson is a Senior Research Associate at Johns Hopkins University with a Master’s of Science degree in clinical psychology   Brain Booster is a premixed dietary supplement that is formulated by Naturamin to naturally enhance cognition. Their website advertises Brain Booster as a nootropic that increases the brain’s ability to learn, remember, and focus. Given these claims, I was excited to give Brain Booster a try and test these assertions. I decided to take Naturamin’s recommended dose of Brain Booster (i.e., two tablets equal to roughly two grams) per day over the course of a week in order to
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Phenylpiracetam Review- 4 Experience Reports

Phenylpiracetam is easily the most stimulating of the piracetam derivatives. Numerous reports across various nootropic forums attest to phenlypiracetam’s ability to enhance motivation, drive, focus and energy levels.   Structurally, the modification is similar to a phenylethlamine (PEA) molecule being added on. PEA is a well documented stimulant that increases dopamine and adrenaline release. Common sense would classify this compound as more of  a stimulant, rather than everyday “true” nootropic, as there’s well noted tolerance with even moderate term use.  As such, my experience report listing was not a straight 1 or 2 week run as I’ve done before with CILTEP. Instead, below
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Semax Profile Added!

Semax is one of those little-known nootropics, that really deserves more attention. Developed in Russia in the 1980s, Semax is a peptide nootropic (lke Selank) which can enhance cognitive function, support mood and promote NGF release. There’s a number of benefits and potential mechanisms of action listed in the article.  Read about Semax here.


3 Calmative Stacks For Focus, Relaxation and Sleep

It’s impossible to get much done with an anxious state of mind. Below are three stacks designed to quell anxiety and keep you calm and relaxed. Of the three stacks, the initial first stack is nutrient based and non habit forming, designed to be taken every day. The second stack, bar selank, is also non habit forming, but designed for a more cognitive enhancing edge rather than just a calm state of mind. The third stack is the most potent by far and is only to be used sporadically as tolerance will develop with frequent enough use. Stack #1 –
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Glycine Writeup Complete

The humble little amino acid glycine has finally got it’s own profile. With benefits geared towards sleep, glycine would appear to be safe, non habit forming and inexpensive. Glycine is certainly worth looking into for those looking to enhance/optimise/hack their sleep with nootropics.  The entire profile has the 3 sleep studies conducted with glycine, in each of them glycine was found to be beneficial. Check out the glycine nootropic profile for detailed information.


Big Omega 3 Writeup Added To The DB

We’ve needed an Omega 3 profile for far too long. It’s always been pushed aside as there’s so much to write about! We’ve covered the basics and some of the less basic. In short – optimizing your omega 3 intake is a must. We’ve got information on dosage, ratios (of omega 3 to 6), a ton of studies relevant to healthy people and a fair deal of information on the mechanisms of action. In short, supplement omega 3 or eat some oily fish. Find out why at our omega 3 profile page.


Creatine added to the database

We’ve needed a solid write up on creatine for a while. Best thought of as a pseudo nutrient, creatine is produced naturally by the liver in sub-optimal amounts, and it would appear supplementation increases muscle/brain creatine stores thereby providing a modest cognitive benefit. Effects seem to be more relevant for vegetarians (who’s dietary intake is low due to no-meat) and the elderly. In healthy people, creatine enhances maximum strength, improves exercise performance and provides protection against cognitive deficits associated with sleep deprivation. It’s safe, cheap and effective! Check out the entire creatine profile page for all the science.


Selank and Caffeine Profiles added!

We’ve added two in depth profiles to our database, Selank and Caffeine. The two compounds couldn’t be much further apart, caffeine being a very well known stimulant that the vast majority of people are acquainted with, while selank is an anxiolytic (semi) research peptide developed in Russia that few people have heard of. The initial research on selank we’ve dug up looks promising. In the weeks to come, we’ll be publishing a selank day by day trial which puts the compound to the test.


My Modafinil Fueled All Nighter – With Cognitive Tests

Pulling an all-nighter is something most of us have done from time to time. Whether it’s changing shift patterns, cramming for exams or meeting an all important work deadline, there’s usually a reason as to why a night’s sleep gets sidelined. Sometimes there just aren’t enough hours in the day and it’s time to burn the midnight oil. I’ve been intending to test the efficacy of modafinil for an all-nighter for a good few months, particularly after reading the following 64 hour sleep deprivation study. The Military Sleep Deprivation Study In 1995 the Canadian defense and civil institute of environmental
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The “Best” Nootropic? Don’t Believe The Hype

I spend a great deal of time browsing Reddit, Longecity and discussing nootropics with people over email. Often,  newcomers ask one of the following questions: “What’s the best nootropic?” “What’s the best nootropics stack?” “What’s the best nootropic for studying?” It seems to be a common line of thinking. Indeed, looking at Google search statistics, you’ve got 100s people plugging in these sorts of terms on a daily basis. I expect this only to grow as nootropics become more popular. Perhaps you even found this post by typing one the above terms into Google only moments ago. If that’s the
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3 Powerful Motivation Stacks I Keep Handy

Generally speaking, I’m not a poorly motivated person. I catch a reasonable amount of sleep, exercise frequently and for the most part, I’m reasonably productive. But when I come to a task I really don’t want to do,  I can turn into a master procrastinator. And while there’s many well established methods of coping with procrastination, I’ve found lighting a fire under me with a stimulant/drive/motivation stack can be highly effective. Over the past 2 years, I’ve experimented with a number of nootropics and stimulants which I’ve found very helpful for getting me through the most banal of tasks. Below are three
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Ultracholine Review – A Premium Cholinergic Formula

Ultracholine is a recently released nootropic formula brought to the market by Mind Nutrition which aims to support acetylcholine and cholinergic processes in the brain. Indeed the tag line for the product is “brain nutrient replenishment”. Looking To Purchase Ultracholine? If you’re interested in purchasing Ultracholine, please consider the below links. Your purchase supports SmarterNootropics.  Worldwide:: Mind Nutrition Store Initial Impressions I was sent a 30 capsule “sample” bottle of Ultracholine for this review. Far from being a simple CDP or GPC choline supplement, Ultracholine contains 7 separate ingredients (listed below) all of which appear to be aimed at acetylcholine formation
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Centrophenoxine Profile Added

We’ve added a detailed centrophenoxine into our nootropics database. Centropheoxine is a cholinergic nootropic and DMAE ester, capable of crossing the blood brain barrier. Be sure to leave a review at the bottom of the profile page if you’ve used it.


5 Interesting Research Nootropics

The following is guest post from Alex at Nootropics Supplement Review. You can learn more about research nootropics at their website. As exciting as the science of nootropics has become in the recent years, things appear to be looking even brighter and more promising for those who are keen on pushing their mental abilities further than what was once thought as possible. There seems to be no stopping the development of newer substances that are even more potent and are more effective cognitive enhancing agents.  At present, there are already several cognitive enhancing agents that are available commercially to research scientists and
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Supporting Acetylcholine With Nootropics

The following is a guest post by Eric Balaster who is the co-founder of Pure Nootropics. His interest in nootropics first developed when his grandfather needed racetams to improve memory in old age. The Importance Of Choline Choline is one of the most important micronutrients for brain health and is vital for the synthesis of the neurotransmitter acetylcholine and cell membranes. Despite choline’s importance, research has uncovered that less than 10% of the American population regularly consumes the recommended daily intake which is 400-550mg per day. Dietary choline has an integral role in physical and cognitive function; deficiency can lead
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Lion’s Mane Mushroom Writeup!

We’ve added an in depth nootropic profile for lion’s mane mushroom. As a potent NGF simulator, recent research has demonstrated lion’s mane is able to reduce depressive symptoms in postmenopausal women and significantly reduce cognitive deficit the the elderly.


CILTEP Stacks: Caffeine, Modafinil and Racetams

After my previous post “a week with CILTEP” which was around 8 weeks ago, I’ve continued to take the formula on a daily basis – bar weekends for tolerance. I’ve experimented with all of my usual nootropics including modafinil and would like to share how things have gone. How I’ve Gone About This Certainly nothing too scientific. I take CILTEP Monday-Friday with a few slight exceptions and it’s always been a serving of 3 capsules first thing in the morning. The substances I’ve reviewed have been taken multiple times on separate occasions so I can get a good feel for
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CILTEP Stack Review : A Week With CILTEP

What Is the CILTEP Nootropic Stack? CILTEP is an acronym for Chemically Induced Long Term Potentiation. It’s a nootropic stack designed to enhance long term potentiating (LTP) – a cellular mechanism responsible for memory encoding between neurons. LTP works by strengthening connections (synapses) between neurons and underlies synaptic plasticity, thus impacting learning and memory. Want To Purchase CILTEP? If you’re interested in purchasing CILTEP, please visit consider the links below. Your purchase supports smarter nootropics. US / Worldwide customers can order though the Natural Stacks website, while UK and EU users can now order CILTEP from our UK based affiliate
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The Best Racetam? A Comparison Of The Popular Racetams

The racetams are an interesting set of nootropics. While it’s true they do share many common benefits, I’ve found each racetam has its own nuances and traits. I suppose a good analogy would be to compare the racetams to fine wine; while white, rose and red wine are all essentially fermented grapes, each has their own subtle taste differences that make them unique. Each racetam (in my opinion) has strengths and weaknesses that make it more or less suitable as a nootropic for a particular situation. Some are stimulatory, some calmative, some focus enhancing and some more suited to creative
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Another Two Profiles: IDRA-21 and PRL-8-53

We’ve gone and added a new section to the nootropics explorer, titled “lesser known nootropics”. We’re putting anything that’s more of a research compound / less mainstream into this category. The first two added are full write-ups on IDRA-21 and PRL-8-53.


Two Profiles Added – Bacopa and Picamilon

We’ve added a full bacopa writeup that includes in depth information about mechanisms of action and potential benefits. In short bacopa looks to be a potent memory enhancing herb that produces some anxiolytic effects. We’ve needed a picamilon page for some time. Sadly writing in true depth was near impossible due to the fact that most of the studies conducted were either in Russian or only available online as abstracts. Still, we’ve managed to cover dose, benefits, stack advice, mechanism of action and safety advice for this nootropic. In short, picamilon is a combination of niacin and GABA that crosses
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Designing Your Own Stack – 3 Important Guidelines

This article is intended to help newcomers design their own stacks and avoid some of the common pitfalls associated with stack design. Feel free to comment/discuss this article below, I’ll do my best to reply. 1. Initially, Keep It Simple The temptation for new users to get started with 10 different nootropics on day one is pretty high. All of these different compounds providing benefits, you should just buy them all and take the “shotgun” approach right? Probably not. There are a few reasons why it’s a bad idea to introduce more than a few new compounds at the same
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Alpha GPC Page Updated

The Alpha-GPC page got a serious re-write. It now has absorption, dosage, side effects and mechanisms of action. At the top of a page is a research summary for those that don’t wish to wade through all the clinical research. Leave a two second review (facility at the bottom of the page) if you’ve used this nootropic before, your reports help other users make better decisions!


Which Choline Source Is Best?

Questions? Feel free to leave a comment below! Choline, in some form, is a component of most people’s nootropic stack, and rightly so. Choline is an essential nutrient which is vital for the production of neurotransmitter acetylcholine and is used to form phosphatidylcholine (PC), a building block of cell membranes. While the benefits of ensuring optimal choline intake are usually highlighted across the internet, it’s difficult to find a comparison of the various choline supplements. This article will cover the differences between Alpha GPC, CDP Choline and Choline Bitartrate. Choline Bitartrate and Lecithin Looking To Purchase? USA and Worldwide: Absorb Health
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Phenylpiracetam Added

We’ve now included a phenylpiracetam page on our nootropics database. Be sure to leave a review if you’ve used this nootropic before, we’d love to hear your thoughts.


Modafinil – How To Maximise It’s Potential

Modafinil (Provigil, Modalert) vs Armodafinil (Nuvigil, Waklert) Before delving into the pointers, it’s important to discuss the differences between Modafinil and Armodafinil. Modafinil is a 50/50 racemic mixture of S isomer and R isomer modafinil while armodafinil contains the R isomer only. One study comparing the two suggests that modafinil suggested that armodafinil had a greater peak in blood levels than modafinil (cmax 5.44 ug/ml vs  4.61 ug/ml respectively),  the study also showed the total area under the curve was 40% greater for armodafinil. Interestingly modafinil also demonstrated a biphasic elimination, with S isomer being depleted first and R isomer
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Start Easy – Go For The Low Hanging Fruit

When talking to nootropic newcomers I often come across people, who understandably, wish to roll their sleeves up and dive right in with a 7 part stack and activate Bradley Cooper overdrive mode. “I’ve seen limitless! Hand me the NZT-48” While I certainly don’t disagree that nootropics can be a powerful ally in the fight for enhanced cognition, it’s important to ensure that the body’s basic needs are met before testing out more advanced nootropic and cognitive enhancement protocols.  This article, by no means complete, is there to bring to light some of the key areas to improve before trialing nootropics.
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Good Starting Stacks For Newcomers

Around half of the questions I receive regarding nootropics are from total newcomers who wish to establish some sort of basic stack for their needs. This post is intended to act as a guide for the nootropics newbie and try to present some simple and effective nootropic stacks that won’t break the bank. 1. Caffeine and Theanine Stack Pros: Inexpensive and effective. Cons: Tolerance with frequent use. Stack Strengths: Counteracts sleep deprivation, increases alertness, enhances focus. Dosage Information: 100-200mg Caffeine, 100-200mg Theanine. Typically taken in a 1:1 or 1:2 ratio (in favor of theanine). Perhaps the simplest nootropics stack that
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Adderall and Methamphetamine

[This is a guest post by Eric Balaster who is the co-founder of Pure Nootropics. His interests in nootropics started when his grandfather needed racetams to improve memory in old age.]   There is no doubt that one of the world’s favorite stimulants is Adderall. Often prescribed for ADD or ADHD, many college students and busy professionals utilize the trademarked concoction without a prescription for enhanced focus, alertness, and motivation. While prescription drugs often offer the illusion of safety, ther e is no denying that Adderall is an amphetamine with many similarities to the methamphetamine that is bought and sold
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Enhanced ATP Synthesis and Cognition with Creatine

[This is a guest post from Eric Balaster who is the co-founder of Pure Nootropics, where he blogs about a wide range of nootropic topics.] Stereotypes abound when creatine enters a conversation. Other than caffeine and omega-3s, it is probably one of the most widely used nootropic compound although it is hardly used for cognitive purposes. Athletes of all types have utilized creatine for decades in order to increase muscle mass and strength. Despite being classified as a popular tool for athletes, taking creatine can help anyone to improve cognitive abilities. While creatine is produced by the body from amino
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Nootropics as an Alternative to Modern ADHD Therapy?

This is a Guest Post by http://www.EliteNootropics.com ADHD is a problem that currently effect around 3-5% of the population. ADHD is characterised by a shortened attention span, restlessness and an inability to concentrate. The group of symptoms frequently presents itself in early childhood and is most diagnosed among males (2:1-3:1 ratio).  The high (and growing) prevalence rate, while alarming, may not include another large portion of individuals that don’t seek help during childhood and remain undiagnosed into adulthood. It is agreeable that ADHD is a large and crippling problem to children, parents and adults. ADHD can affect many aspects of
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Another Profile : Sulbutiamine

Given it’s popularity – the nootropics database was sorely lacking sulbutiamine. Comments are open on the listing, as are the experience reports – if you’ve used sulbutiamine please post a few words on your experience, your review helps other nootropic users!


CDP Choline / Citicoline Profile Added

We’ve just completed an in depth review for cdp choline/citicoline which includes dosage information, absorption and covers most of the human research available. Nootopic experience reports and comments are open on the article page – please take the time to leave a quick review if you’ve got experience using this nootropic.


Adderall Page Updated

We’ve updated our Adderall page with some interesting information on Adderall tolerance and a few words supporting supplements L-tyrosine and Sulbutiamine.  Finally we’ve added some information covering amphetamine excretion under acidic and alkaline conditions. A total of 13 references have been included.


The Silk Road Shutdown

News broke hours ago that the Silk Road, a popular anonymous drugs market, has been seized by the FBI.  Ross William Ulbricht allegedly the ringleader AKA “Dread Pirate Roberts” or “DPR” was arrested “without incident” at a public library in San Francisco on Tuesday. Along with Ulbricht’s arrest, around $3.6m of bitcoins have been seized. Ulbricht has been charged with Nacrotics Trafficking, Computer Hacking and Money Laundering charges. This criminal complaint also alleges that Ulbricht took part in a plot to murder a user of the silk road who threatened to reveal thousands of users identities. A video, apparently of Ulbricht has
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Zoned Review: A New Energy Supplement

Ingredients Find more info at www.getzonedup.com Zoned is a 755mg blend of 5 different Nootropic substances; Zoned consists of 100mg of Caffeine and 655mg of a blend of Sulbutiamine, Choline, Schizandrol A, and Hordenine.  It is recommended that most people take 1 pill daily, or 2 pills for those who are over 200 lbs or have high stimulant tolerance. –          Sulbutiamine is a derivative of Vitamin B1 that is more readily able to cross the Blood Brain Barrier which leads to greater levels of thiamine in the brain.  Oral administration of Sulbutiamine has been shown to have positive effects on
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There have been a slew of posts across multiple forums recently discussing delays in the shipment of orders; specifically of orders for Modafinil and related products.  This has been due to two compounding variables that are outside the control of vendors and suppliers; namely Operation Pangea VI and multiple strikes in India over government intervention into the Pharmaceutical industry. OPERATION PANGEA VI To get a better understanding of Operation Pangea VI, we need to look at the history of Operation Pangea I – V.  From its inception, Operation Pangea has been one of the largest and most successful operations aimed
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Epiphany D1 Review

Epiphany D1 was my first foray into pre-mixed Nootropic stacks, and I must admit I was relatively impressed with the effects I felt; however, anecdotal reports are not as valuable as looking at the actual ingredients and discussing the pros and cons of this particular product.  Epiphany D1 is a combination of 13 Nootropic compounds, and a few other various vitamins and minerals; the Nootropic compounds are Bacopa Monnieri, Acacia Rigdula, Aniracetam, Oxiracetam, Amla, Vinpocetine, Mucuna Pruriens, Alpha GPC, Sulbutiamine, Phosphatidylserine, Caffeine, Theobromine, and N-Methyl-D-Aspartic Acid (NMDA).  Below is a brief breakdown of each ingredient: Bacopa is one of the
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Binary Search; or How to Figure Out Which Nootropic You Are Reacting To

If you’re like most people who use Nootropics, you don’t just use one at a time (often known as stacking); this is a good way to optimize your performance but can present some issues, mainly in making it difficult to determine which Nootropic substance you are reacting to (either positively or negatively).  There are three main ways of determining which Nootropic may be causing your reaction: Google-Fu, Simple Search, and Binary Search.  Each search form has its own merits and disadvantages which I will outline, and show why Binary Search can be one of the strongest and fastest ways to
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Choline and its Different Forms

Brief Overview of Choline Choline is the substance that acts as the precursor to Acetylcholine in the brain; it plays a role in memory formation, attention, and focus.  It is usually recommended that the average adult human get between 425 – 550mg/day of choline; those who take any of the Racetams may or may not need to have a higher intake to combat headaches and brain fog. There are 5 different ways to get choline into your diet: Dietary choline, Choline Bitartrate, Lecithin, Alpha GPC, and CDP-Choline [1]. Dietary Sources of Choline [1] Animal and plant foods Choline (mg) 32
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Brainstack Review

Brainstack is a nootropic blend that comes from Maven Labs and is engineered to help increase the users focus and increase productivity.  The lab believes in user feedback and they formulate Brainstack, similarly to a software developer, by using feedback from consumers to adjust and refine their formulas. For example, the original formula for Brainstack contained Vinpocetine and Oatstraw. Despite positive research to support the effects of Vinpocetine, Maven Labs decided to remove it because of users having a negative reaction to the substance. Maven Labs sent us a sample to test and review for a month; before we discuss
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Alpha BRAIN Review

Alpha Brain is one of the more well known Nootropics on the market today.  It’s gotten a lot of attention from athletes and celebrities like Joe Rogan and his cohorts over at Death Squad.  The question is whether or not the product lives up to the hype. My experience with Alpha brain is limited to a couple doses I took when my brother purchased a bottle about a year ago. The supplement claims a large amount of benefits including, increased focus, memory, enhanced sleep with more vivid, lucid dreams as well as increased athletic performance and antioxidant benefits.  Lets take
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tDCS: Zap your mind into flow state.

When we first heard of this new gizmo that will mess with your brain, we weren’t too impressed… When we learned that it will mess your brain into a state where you can learn 2.5X more effectively, our attention was piqued. What’s this you say a nootropic that can be had using batteries? We had to explore further. Turns out, there is a technology called transcranial direct-current stimulation (tDCS), brought to you by the makers of the internet, that a couple of entrepreneurs decided to replicate for the retail market. Traditionally, units are far more expensive and would remain out
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Happy NYE: from smarternootropics.

I hope you all have a great New Years, 2013!! Since we are all still around, which I suppose means that the Mayans were wrong, lets try to help each other make this year full of cognitive surplus. This post will be left for open discussion. Happy Holidays, Smarternootropics.


Phenibut: quick run down.

Phenibut, is a very sour tasting, water soluble derivative of gamma aminobutyric acid (GABA) (as seen below). To be specific, GABA + phenyl group, which is something that actually aids in crossing the blood brain barrier (BBB). Phenibut is most well known for its anxiolytic effects, and from a physiology standpoint, it makes sense since most anxiolytic drugs (benzodiazapines/barbituates/alcohol) exert their effects upon GABA, in this case specifically GABA(B) more than GABA(A) and is most similar in action to baclofen. Phenibut was developed in russia in the 1960s, where even today most of the research about it is originating from.
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On sulbutiamine, an interesting B-vitamin.

I’ve recently come across a molecule with some interesting properties. Sulbutiamine is a synthetic derivative of thiamine that lends for interesting results. Sulbutiamine is, essentially, thiamine (B1) that is bound together at the thiol group. Sulbutiamine   Thiamine This simple alteration in molecular structure, results in an increased liphophilicity that allows this molecule to penetrate through the blood brain barrier (BBB), with much greater ease. So, if I haven’t lost you yet I’m sure you’re wondering why this is such a great thing? To help understand better the importance of thiamine on the mind, we should first look and see
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Magnesiofy your learning and memory

Sometimes the simplest answers are usually the best. So when I read that MIT found that increasing brain magnesium had a direct effect on learning and memory my ears and eyes sharpened up like a dog that just saw his favorite toy. Fishing through all the huperzine As, racetams, bacopas and dopas sometimes make you forget about the minerals and vitamins that are so important to maximizing normal physiologic function. With that said the focus of this article will be on Magnesium: Magnesium is a phenomenal mineral. As one can easily see it shares a column with Calcium on the
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State Of The Nootropics Address

The world of nootropics is rapidly expanding; already substances that no one knew the name of last year are becoming household terms. Knowledge of pharmacology and substances beneficial to mind and body is becoming colloquial slowly but surely as the availability of knowledge increases through such readily available channels as the internet. One downside to such a rapid expansion in knowledge is that incorrect information is as readily available as correct information and deciphering the difference between the two can become a task of great monument to just about anyone. One of the most common issues, with respect to disinformation
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Trying to get smarter? there’s a bac(teria) for that.

Researchers at the University of Texas Health Science Center in San Antonio have recently found a bacterial byproduct that has made young mice learn better and negates cognitive decline in old mice. The bacterial byproduct was found on Easter Island, an island that is ~ 2000 miles from any centers of population and riddled with over 900 mysterious monolithic statues. Rapamycin is the product produced in the mysterious bacteria (Streptomyces hygroscopic us) from Easter Island, which is traditionally deployed in transplant patients as an antifungal in attempt to help stop rejection. It is named after the Indonesian name for Easter Island,
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Alzheimer’s Disease is neural diabetes? Why keeping your blood sugar tight might keep you smarter.

While perusing articles this week I came across something I had to write about. It seems as thought researchers at Brown University have established a link between insulin resistance found in the brain and Alzheimer’s disease (AD). When I first read this claim, in relation to the destruction of peripheral nerves that occurs under such pathology, the brilliance of this tie was truly awe inspiring and only left me with the question: why has this taken this long to figure out? To refresh, in diabetes, pathology of sugar utilization that leads to metabolic imbalance, the peripheral nerves begin to die
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