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Bromantane

Bromantane

Other Names [1]

N-(4-bromophenyl)adamantan-2-amine,

Ladasten,

Bromantan,

tricyclo[3.3.1.13,7]decan-2-amine, N-(4-bromophenyl)-,

aniline, N-(2-adamantyl)-4-bromo-


Bromantane’s Background

Bromantane has been used in Russia since the late 1980s without a prescription by sportsmen and soldiers[2][3]. It is an adamantane derivative and was originally developed as an immuno-stimulant drug. Bromantane is simultaneously a stimulant and an anxiolytic[4]. In 1996 it was listed in the IOC list of prohibited substances shortly after it was discovered being used by several athletes in that year’s Olympic Games[3].


Bromantane Modes of Action

  1. Bromantane stimulates the nervous system through dopaminergic action[5]

  2. Bromantane stimulates serotonin receptors by increasing 5-HT and 5-HIAA in the frontal cortex and subcortical regions of the brain[5]

  3. Bromantane reduces 5-HT and 5-HIAA in the cerebellum[5]

  4. Bromantane strengthens GABA-ergic mediation, reducing gene expression, supervising synthesis of GABA-transporters[6]

  5. Bromantane stimulates synthesis of cytochrome P-450[6]


Bromantane Benefits

  1. Increases both mental and physical work capacity[6]

  2. Increases learning and memory[6][8]

  3. Stimulant effect differs from traditional psychostimulants in that it is an agent of non-exhaustive action (no increase in oxygen consumption or body heat). [6]

  4. Reduces anxiety[4][6]

  5. Boosts immune system[6]

  6. Increases muscle mass and strength[7]

  7. Reduces overheating and helps protect against hyperthermia

  8. Very few side-effects[6]

  9. No withdrawl symptoms or addictive potential[6][7]

  10. Helps liver with detoxification functions[6]


Dosing Bromantane

Bromantane dosing appears to be sex-dependent. When taken orally, bromantane is quickly absorbed by the gastrointestinal tract into the bloodstream (42%). Bromantane is highly lipophilic. Females absorb bromantane significantly quicker than males and therefore in females bromantane a much shorter half-life in females as opposed to males. Time to achievement is 2.75 hours in females and 4 hours in males.[6]

The effective dose for bromantane is 30mg/kg in the rat. At 30mg/kg, bromantane has a stimulant effect. At toxic doses (600mg/kg), bromantane has a sedating effect.[6][7]


Bromantane Toxicity

In animal studies, toxicity was reached only at very high levels of administration. Toxic effects begin around 600mg/kg in mice[6][7] and the LD50 is much higher in one animal study performed in Russia of 8100mg/kg injected intraperitoneally.[8]


Sources

1. CSID:3849628, http://www.chemspider.com/Chemical-Structure.3849628.html (accessed 21:30, Apr 22, 2013)

2. Schänzer, W. Recent Advances in Doping Analysis: Proceeding of the Mandred Donike 16th Cologne Workshop on Dope Analysis, 15th to 20th March 1998. Köln: Sport Und Buch Strauss, 1999. Print.

3. Thieme, Detlef, and Peter Hemmersbach. Doping in Sports: Biochemical Principles, Effects and Analysis. N.p.: Springer, 2009. Print.

4. http://www.ncbi.nlm.nih.gov/pubmed/10439937

5. http://www.ncbi.nlm.nih.gov/pubmed/7580761

6. Oliynyk, Sergiy, and Seikwan Oh. “The Pharmacology of Actoprotectors: Practical Application for Improvement of Mental and Physical Performance.” Biomolecules & Therapeutics (2012): 444-55. Print.

7. http://www.ncbi.nlm.nih.gov/pubmed/11109517

8. http://www.ncbi.nlm.nih.gov/pubmed/10340117

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