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Other Names

Ampelopsin, (2R,3R)-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydrochromen-4-one, (CAS Number) 27200-12-0, (PubChem) 161557, (ChemSpider) 16735660, C15H12O8

Dihydromyricetin’s Background

Dihydromyricetin is found in the Hovenia dulcis tree, also known as the Oriental Raisin Tree; the leaves of the tree have been brewed as a tea in the Near East for centuries, and in 2008 was approved by the Korean FDA for use as a treatment for alcoholism.  Dihydromyricetin has also been shown to be effective in treating oral ulcers [2], and antioxidant properties [4].

Dihydromyricetin Mechanism of Action

Dihydromyricetin appears to have two Mechanisms of Action that allow it to accomplish its two main benefits: the anti-oxidative effects of dihydromyricetin appear to be due to its ability to remove Fe and Fe2+ ions from the body; both Fe and Fe2+ are heavy metals that can have negative effects on the body when present in higher amounts [4]. The second mechanism of action for dihydromyricetin is acting as an antagonist for the GABA(A) receptors in the brain; these receptors are potentiated when a person is in a state of acute alcohol consumption.  On a related note, dihydromyricetin also has been found to improve GABA(A) receptor plasticity in alcohol withdrawal and tolerance [6,13].

Dihydromyricetin Benefits

Dihydromyricetin has shown some interesting effects such as reducing the proliferation of liver carcinoma cells, specifically HepG2 Cells [1], and showing anti-oxidative effects in the form of lipid peroxidation [4].  Beyond these effects, dihydromyricetin is most well-known for its ability to counteract acute alcohol intoxication in rats and reduces the effects of tolerance and withdrawal in rats.  It was also shown that dihydromyricetin had the ability to reduce voluntary alcohol consumption when rats were placed in such a situation [6,13].  Due to these effects, dihydromyricetin has been indicated as a possible treatment for Alcohol Use Disorders.

Dihydromyricetin Dosing

An injection of 1mg/kg of dihydromyricetin in rats was found to be effective in counteracting alcohol intoxication; this scales to .244mg/kg in humans, or 17.112 mg per day for a 70kg human (150lbs person) [6].

Dihydromyricetin Toxicity

Up to 200mg/kg of dihydromyricetin was given to rats and found to have no negative side effects; this scales 48.892mg/kg in a human, or 3422mg for a 70kg person (150lbs person) [2].

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Gao Q, Yang X, Ou M. Effect of serum containing tengcha total flavonoid and dihydromyricetin on proliferation and apoptosis of HepG2 cells. Zhongguo Zhong Yao Za Zhi. 2011 Feb;36(4):500-3. [1]

Yang XM, Wang XH, Chen LF, Wang XQ. Effects of dihydromyricetin on tumor necrosis factor and NF-kappaB p65 of RAU rats. Zhongguo Zhong Yao Za Zhi. 2012 Sep;37(17):2612-7. [2]

He GX, Yang WL, Pei G, Zhu YH, Du FL. Studies on the effect of dihydromyricetin on antilipid-peroxidation. Zhongguo Zhong Yao Za Zhi. 2003 Dec;28(12):1188-90. [3]

Zhang YS, Ning ZX, Yang SZ, Wu H. Antioxidation properties and mechanism of action of dihydromyricetin from Ampelopsis grossedentata. Yao Xue Xue Bao. 2003 Apr;38(4):241-4. [4]

Chen T, Zhu S, Shang Y, Ge C, Jiang G. Binding of dihydromyricetin to human hemoglobin: fluorescence and circular dichroism studies. Spectrochim Acta A Mol Biomol Spectrosc. 2012 Jul;93:125-30. doi: 10.1016/j.saa.2012.02.109. Epub 2012 Mar 7. [5]

Shen Y, Lindemeyer AK, Gonzalez C, Shao XM, Spigelman I, Olsen RW, Liang J. Dihydromyricetin as a novel anti-alcohol intoxication medication. J Neurosci. 2012 Jan 4;32(1):390-401. doi: 10.1523/JNEUROSCI.4639-11.2012. [6]

Chen L, Wang C, Wei Q, Ning Z, Yuan E. Interaction of dihydromyricetin and alpha-amylase. Nat Prod Commun. 2013 Mar;8(3):339-42. [7]

Zhang Y, Que S, Yang X, Wang B, Qiao L, Zhao Y. Isolation and identification of metabolites from dihydromyricetin. Magn Reson Chem. 2007 Nov;45(11):909-16. [8]

Chen T, Zhu S, Lu Y, Cao H, Zhao Y, Jiang G, Zhu L, Lu T. Probing the interaction of anti-cancer agent dihydromyricetin with human serum albumin: a typical method study. Anticancer Agents Med Chem. 2012 Oct 1;12(8):919-28. [9]

Jin MY, Ding Y, Zhang T, Cai ZZ, Tao JS. Simultaneous Determination of Dihydromyricetin and Resveratrol in Ampelopsis sinica (Miq.) W.T. Wang by High-Performance Liquid Chromatography Coupled with a Diode Array Detection Method. J Chromatogr Sci. 2013 Apr 24. [10]

Agrawal PK, Agarwal SK, Rastogi RP. Dihydroflavonols from Cedrus deodara. Phytochemistry Vol 19, Issue 5, 1980 Pg 893-896. [11]

Champeau R. Chinese herbal medicine may provide novel treatment for alcohol abuse. UCLA Health and Medicine Newsroom. [12]

Yi Shen, A. Kerstin Lindemeyer, Claudia Gonzalez, Xuesi M. Shao, Igor Spigelman, Richard W. Olsen and Jing Liang. Dihydromyricetin As a Novel Anti-Alcohol Intoxication Medication. The Journal of Neuroscience, 4 January 2012, 32(1): 390-401; doi: 10.1523/JNEUROSCI.4639-11.2012. [13]