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Other Names:

(RS)-2-(diphenylmethylsulfinyl)acetamide, Provigil, Modalert, Modiodal, Alertec, Modavigil, Carim, Modasomil, Resotyl, Stavigile, Vigia, Vigil.

Important Information

Dosage Information:

Generally 50-200mg would be a reasonable dose. With such powerful stimulants, starting small is always a good idea. Consider taking 50mg upon waking and assess from there. If using for sleep deprivation purposes, consider 50-100mg every 8 hours.

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  3. Modafinil – How To Maximise It’s Potential
  4. 3 Powerful Motivation Stacks

Modafinil Background:

Modafinil is a, Schedule IV, racemic CNS stimulant with unique properties. Secondary to its indicated uses, modafinil is currently classified as a wakefulness promoting agent. Its pharmacologic profile is most likened to something in between methylphenidate and amphetamine [3]. Modafinil is currently indicated to treat: excessive sleepiness associated with narcolepsy, obstructive sleep apnea/hypopnea syndrome, and shift work sleep disorder.

Active ingredients:

(RS)-2-(diphenylmethylsulfinyl)acetamide (Modafinil).

Inactive ingredients:

lactose, microcrystalline cellulose, pregelatinized starch, croscarmellose sodium, povidone, and magnesium stearate [3].

Modafinil’s Mode of action:

The exact mode of action of modafinil remains elusive; as such, studies in rats, have revealed that the mechanism by which modafinil operates is centered around CNS levels of histamine. After dosing modafinil, there was shown to be an increase in both histamine, centered in the anterior hypothalamus, and locomotor activity. Moreover, once effective dosage of each was reached, the increase in locomotor activity resulting from modafinil was seen to be on par with that of methylphenidate. It was also noted that, unlike methylphenidate, when α-fluoromethylhistidine, a potent inhibitor of histidine decarboxylase, was administered and neuronal histamine concentration were depleted, so was modafinil’s effects [7].

In other studies, modafinil was found to piggyback the orexinergic systems, in mice. It was found that, in orexin neuron-ablated mice, modafinil failed to mount an effect, suggesting hypothalamic orexinergic neurons role within modafinil’s histaminergic pathway, primary. Furthermore, it has been postulated that modafinil increases hypothalamic histamine via attenuation of the GABAergic neurons that influence the orexinergic system [6].

Benefits Of Modafinil:

The primary benefit for which modafinil is currently prescribed is in wakefulness promoting. In normal conditions, sleep deprivation has been shown to impair hippocampal-dependent memory. Modafinil has been shown to prevent impairment of cognitive function by reducing the number of errors compared to placebo and by upregulating synapsin I expression within the dorsal hippocampus [5]. In a study involving sleep deprived ER physicians, modafinil displayed ability to improve performance on tests of higher cognitive function, compared to the baseline, albeit, failed to show gains in performance, with respect to psychomotor tasks [9]. Similarly, in studies concerning patients dependent on methamphetamine, modafinil showed a direct relationship between cognitive improvement and amount of methamphetamine use [2].

There have been attempts, by the owners of the original patent, to clear modafinil as indicated for conditions of  ADHD/ADD. However, such attempts have proven unwielding; as study after study has proven it ineffective for purposes of attention deficit in adults [1]. In children, however, when compared to methylphenidate, using the Test of Variables of Attention, modafinil proved to be as effective as when considering the improvements seen [4].

Modafinil Side Effects:

Weight loss, decreased appetite, insomnia, headache, nausea, nervousness, dry mouth, and hypertension.
May have some abuse potential, although none have been reported to date [8].

Other Information:

Both British and American military units are known to use modafinil to improve cognitive functioning in extended low-sleep, high-stress scenarios. Tactical paramedics in Maryland administer modafinil to police and law enforcement when they are dealing with high-risk, large-scale operations in order to increase functioning and alertness. The French Foreign Legion has admitted to giving its soldiers modafinil during covert operations. It is also used by astronauts on board the International Space Station.A study of modafinil’s use in US Helicopter Pilots showed that given modafinil, pilots were able to function at normal levels for up to 40 hours with no sleep.











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 2 reviews
by Hirmlocke on Blank Product Name
Dirtier than coffee

I don't like this one too much. It doesn't remove tiredness too much. It feels like it just forces you to be awake while getting more tired. It doesn't remove the tired feeling too much. It's like having insomnia(where you're tired, yet something forces you to be awake and you get even more tired). Modafinil also causes jitters. Fluorenol(sometimes called hydrafinil) is more effective at removing the tired feeling. Fluorenol feels smoother and makes you feel alert. Fluorenol is stronger and smoother than modafinil and feels like a far more effective wakefulness enhancer. Fluorenol also stacks well with cyclopentamine, though cyclopentamine's hard to find nowadays. Modafinil just seems like overpriced crap.

by sleepnomore on Blank Product Name
Perfect For Sleep Deprevation

I work night shifts and typically get 5 days notice from work as to when my next "night" is going to be. This makes it hard to ajust to any sort of regular sleep pattern. My typical waking day is 7AM-10PM however my "nights" are 8PM-8AM.

I initially tried energy drinks like everyone else on the shift, but it left me feeling tired after a few hours. After reading about modafinil I thought to give it a shot. 100mg taken at 8pm (start of night shift) and another 100mg taken at 2-3AM and I am though the night shift with ease.

As I'm a student I have tried modafinil for study, it does help somewhat, but I find adderall more effective, so I'm giving this 4 stars.