pyridoxal phosphate, pyridoxine, pyridoxine 5’-phosphate, pyridoxal, pyridoxal 5’-phosphate, pyridoxamine, pyridoxamine 5’-phosphate, 4-pyridoxic acid
Vitamin B6 Background
In its various forms, Vitamin B6 is a water-soluble vitamin that occurs naturally in a wide variety of foods. It plays a role in over one hundred forty enzyme reactions related to the metabolism of amino acids, carbohydrates, neurotransmitters and lipids.  Its many functions are linked to numerous health benefits. In addition to its prominent presence in meats, starchy vegetables and non-citrus fruits, Vitamin B6 is also frequently offered in multivitamins or as an individual dietary supplement. 
Vitamin B6’s Mode of Action
This vitamin’s mode of action as far as its nootropic qualities are concerned is a matter of some discussion. Vitamin B6 is present in so many of the body’s physiologically significant functions that isolating a direct causal correlation between Vitamin B6 consumption and the treatment of a specific condition has proven difficult. A common hypothesis is that Vitamin B6, often in conjunction with other B vitamins, can reduce cognitive impairment and brain atrophy by lowering the associated elevated homocysteine levels in the bloodstream.  Studies have demonstrated, however, that while the intake of B6 and other vitamins can reduce homocysteine levels and decelerate brain atrophy, it is not an effective method of preventing or curing cognitive impairment.    
Vitamin B6 – Benefits
Because of its involvement in so many enzyme reactions, benefits of healthy Vitamin B6 intake are often subtly visible across the spectrum of health-related concerns. In addition to its uses for normalizing homocysteine levels to slow cognitive degeneration and prevent cardiovascular disease, it has been shown to help decrease risks of colorectal cancer in a study of postmenopausal women , maintain healthy blood sugar levels  and treat pregnancy-related nausea . There are numerous other benefits and applications for Vitamin B6, both for standard daily health and for the treatment of developed conditions.
Vitamin B6 Dosing
For most adults, the recommended daily consumption of Vitamin B6 is 1.3 mg. This amount is easily obtainable from a balanced diet including foods such as meats, legumes, poultry and whole grains.  A daily intake of 100 mg is considered safe and the no-observed-adverse-effect level is 200 mg daily. 
Vitamin B6 Toxicity
Because Vitamin B6 is transported passively, potentially toxic doses can be absorbed . Repeated high doses can result in ataxia, nerve damage, numbness, skin lesions, and photosensitivity  .
Conversely, Vitamin B6 deficiency can also have adverse effects. Confusion, depression, mouth sores and decreased efficacy of the immune system can all result from low intake  .
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