CILTEP is an acronym for Chemically Induced Long Term Potentiation. It’s a nootropic stack designed to enhance long term potentiating (LTP) a cellular mechanism responsible for memory encoding between neurons. LTP works by strengthening connections (synapses) between neurons and underlies synaptic plasticity, thus impacting learning and memory.
Want To Purchase CILTEP?
If you’re interested in purchasing CILTEP, please visit consider the links below. Your purchase supports smarter nootropics. US / Worldwide customers can order though the Natural Stacks website.
USA and Worldwide: Natural Stacks
How Does CILTEP Work?
So how can LTP be enhanced by nootropics? The theory behind the CILTEP stack is that by enhancing cyclic adenoside monophosphate (cAMP) we facilitate complex intracellular mechanism that eventually lead to enhanced synapse strength (LTP). Â cAMP is enhanced in two ways:
Inhibiting cAMP breakdown
This is typically done with phosphodiesterase 4 (PDE) inhibitors. In the CILTEP stack, this is the function of Artichoke.
Directly increasing CAMP creation
This is achieved with forskolin, a herbal extract from coleus forskohlii, which raises cellular cAMP levels. Forskolin is frequently the “go to” agent scientists use when they want to study the effects of cAMP.
The CILTEP stack also contains Acetyl L-Carnitine (ALCAR) for acetylcholine support, and phenylalanine. This is a precursor to dopamine and noradrenaline, which are neurotransmitters involved with motivation and alertness respectively.
My CILTEP Review
I had somewhat high hopes going into this experiment given the large number of benefits reported by users on Longecity. Reports of increased motivation, ability to learn, enhancement of stimulants (a big plus for me) and mood improvements seemed pretty enticing. CILTEP also seemed an alternative to the racetam/choline stack that potentially could be stacked in addition as CILTEP works through different mechanisms.
I consumed the natural stacks CILTEP product, which contains (per 3 capsule serving):
- 900mg Artichoke (5% minimum caffeolyquinic acids) – PDE Inhibitor
- 4mg forskolin (20mg extract minimum 20% standardized) – Enhances CAMP release
- 500mg Phenylalanine – Building block for dopamine and noradrenaline.
- 750mg ALCAR – Acetylcholine support
- 5mg Vitamin B6 – Cofactor for neurotransmitter synthesis.
Day 1 – CILTEP Solo
I consumed 3 capsules of CILTEP at 12 noon with a light meal consisting of a small amount of fat, for maximum absorption. Initial effects were felt around an hour later; I began to feel chatty, talkative and particularly interested with my workload. I naturally dismissed this as a placebo effect, though it persisted for a good 5-6 hours after consumption. I got through my workload in my regular amount of time, but I felt very positive about everything I was doing. Thoughts seemed to flow better.
Day 2 – CILTEP Solo
After a fine night sleep, I awoke with my usual sense of self and consumed a serving of 3 capsules on an empty stomach. I had read that forskolin is best absorbed with fat, but considering the bottle recommends an empty stomach, I threw caution to the wind. I wasn’t disappointed. As with day 1, around an hour after dosing I noticed a subtle, yet definite “motivated” feeling that I can best describe as enhanced mental energy.
I noted no “body high” and my resting heart rate and blood pressure were their usual selves. I got through my day of work and felt a certain hunger to better understand the inner workings of a few concepts. During conversations with people I found myself at greater ease and a little more confident, though nothing too dramatic. All in all, I suppose you could wrap it up as me on a good day.
Day 3 – CILTEP + Caffeine + Theanine
I decided to push the boundaries a bit and consume CILTEP with a serving of caffeine and theanine (1:1 ratio, 100mg:100mg). I have both powers on hand, so didn’t consume the premade natural stacks caffeine/theanine product (as recommended on the website); I just mixed my own powders.
I’m fairly stimulant sensitive, so I normally expect a boost from such an addition, but the combination CILTEP certainly increased the boost I was expecting. It was essentially like I’d had a double the dose of caffeine; both physical and mental energy were greatly increased and I noticed an unfortunate effect of a pounding heart. Probably should have cut back on the caffeine a little!
Aside from the enhanced stimulant effect, I found CILTEP + caffeine+ theanine fantastic for creative thought. I worked through my usual daily tasks with ease and found myself with plenty of energy to spare. I ended up completing a mindmap for a future project and was pleased with the ideas that came to mind. I had a slight rough time getting to sleep on day 3, due to the increased response to caffeine, so I ended up consuming 500mg of phenibut before bed. In the future, I’ll consume less caffeine with this stack.
Days 4 & 5 – CILTEP + Piracetam + CDP Choline
I trialed the stack with my typical piracetam (2.4g) and CDP choline (500mg) morning. I found this a pretty awesome stack that allowed me to remain creative and focused, without feeling so withdrawn that I didn’t wish to converse with anyone. I was sociable for most of the day and found myself enjoying conversation more than usual.
No staggering difference, but a definite change that resulted in a more focused version of me, that I typically rely on stimulants to provide. Â I felt like a sharper version of myself and was generally clear headed.
Days 6 & 7 – A Break For Tolerance
I gave the stack a break as per the manufacturer’s instructions. I personally didn’t notice any tolerance issues, but I felt it best to follow their guidance in an effort to make this a fair review.
Days 8, 9 & 10 – CILTEP + Piracetam + CDP Choline
I kept the addition of piracetam and CDP choline (as with days 4+5). I felt pleased to be back “on” the stack and to be back to my “sharpened” state. Interestingly enough, I began looking through one of my notebooks where I keep ideas and was pretty surprised with my previous weeks output. Days 8,9,10 pretty much paralleled days 4 and 5, with a subtle but definite increased desire to learn and “get stuff done”.
- Enhanced stimulant effectiveness (something to watch out for if you’re sensitive)
- Around 6-8 hours subjective difference from time of consumption
- Seems to sit with other nootropics nicely (I stacked piracetam+CDP choline)
- Enhanced motivation, ability to learn and desire to learn
- Greater mental clarity, slight enhanced ability to focus/concentrate
- I cycled 5 days on, 2 off.
- Time will tell if memory enhancements “stick”, I remain optimistic!
I was particularly impressed with CILTEP’s fast onset, something I wasn’t expecting. I’ve found that some nootropics can take days or weeks (rather than hours) to kick in, which makes it hard to notice a subjective difference. CILTEP certainly improved my mood and made me feel more positive and sociable; I’d chalk both the mood and motivating effects up to enhanced mental energy.
I particularly enjoyed the synergy with caffeine and will experiment with other stimulants. The piracetam / CDP choline combo worked very well together and I was satisfied that I was a reasonable degree above baseline cognition. CILTEP is certainly something I’ll continue to use for the foreseeable future. I’m still a little skeptical that a stack so noticeable couldn’t have some sort of tolerance so I’ll stick to the recommended 2 days / week off.
Want To Purchase CILTEP?
If you’re interested in purchasing CILTEP, please visit consider the links below. Your purchase supports smarter nootropics. US / Worldwide customers can order though the Natural Stacks website, while UK and EU users can now order CILTEP from our UK based affiliate smartnootropics.
USA and Worldwide: Natural Stacks